Apathy Secondary to Neurologic Disease

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Apathy secondary to neurologic disease
James D Duffy and Ravi Kant

The phenomenology and treatment response of secondary psychiatric disorders provides a valuable model for exploring the pathophysiology of primary psychiatric disorders. This article provides a broad overview of (1) case reports that have applied a “lesion analysis” approach in studying apathy and related disorders of diminished motivation (ADDM) and (2) studies that have used standardized assessments of apathy in well-defined populations of patients with neurologic disorders. This rapidly expanding clinical database provides a valuable resource for defining the neural substrates of motivation and its clinical disorders. Psychiatric Annals 27:1/January 1997